Protein Details: Two pore calcium channel protein 1

Protein ID

ICDB_Pro_1388

Protein Name

Two pore calcium channel protein 1

Gene Name

TPC1; CCH1; FOU2; At4g03560; F9H3.19; T5L23.5

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

733 amino acids

AlphaFoldDB

AF-Q94KI8-F1-model_v4.pdb

Function

Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the vacuole membrane. Is one of the essential components of the slow vacuolar (SV) channel. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Involved in the regulation of germination and stomatal movement.

Sequence

MEDPLIGRDSLGGGGTDRVRRSEAITHGTPFQKAAALVDLAEDGIGLPVEILDQSSFGESARYYFIFTRLDLIWSLNYFALLFLNFFEQPLWCEKNPKPSCKDRDYYYLGELPYLTNAESIIYEVITLAILLVHTFFPISYEGSRIFWTSRLNLVKVACVVILFVDVLVDFLYLSPLAFDFLPFRIAPYVRVIIFILSIRELRDTLVLLSGMLGTYLNILALWMLFLLFASWIAFVMFEDTQQGLTVFTSYGATLYQMFILFTTSNNPDVWIPAYKSSRWSSVFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVSGMDQMKRRMLEKAFGLIDSDKNGEIDKNQCIKLFEQLTNYRTLPKISKEEFGLIFDELDDTRDFKINKDEFADLCQAIALRFQKEEVPSLFEHFPQIYHSALSQQLRAFVRSPNFGYAISFILIINFIAVVVETTLDIEESSAQKPWQVAEFVFGWIYVLEMALKIYTYGFENYWREGANRFDFLVTWVIVIGETATFITPDENTFFSNGEWIRYLLLARMLRLIRLLMNVQRYRAFIATFITLIPSLMPYLGTIFCVLCIYCSIGVQVFGGLVNAGNKKLFETELAEDDYLLFNFNDYPNGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYVITILLLLNLVVAFVLEAFFTELDLEEEEKCQGQDSQEKRNRRRSAGSKSRSQRVDTLLHHMLGDELSKPECSTSDT

PDB Structures

5DQQ 5E1J 5TUA 6CX0 6E1K 6E1M 6E1P 7FHK 7FHL 7FHN 7FHO 7TBG 7TDD 7TDE 7TDF

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Ubiquitously expressed

DOI ID

10.1093/pcp/pce145; 10.1038/nature03381; 10.1038/47134; 10.1111/tpj.13415; 10.1016/s0005-2736(02)00509-6; 10.1016/j.bbrc.2004.09.015; 10.1093/jxb/erm035; 10.1074/mcp.m600250-mcp200; 10.1093/pcp/pcm151; 10.1111/j.1365-313x.2006.03002.x; 10.1074/mcp.m111.015131

RefSeq

NP_567258.1